Bone construct, in combination with a Mediterranean-style, low-glycemic-load diet and aerobic exercise, has been clinically shown in postmenopausal women to beneficially influence key biomarkers of bone remodeling more than diet and exercise alone. -Features berberine and selective kinase response modulators (SKRMs) derived from hops—reduced iso-alpha acids (RIAA)—which target metabolic processes related to bone health. -Provides Vitamin K, a key vitamin in the metabolism of bone proteins crucial to bone integrity. -Supplies Vitamin D, associated with bone formation and bone mineralization. -All-natural formula without serious adverse effects.